Dev Biol. Howard Y. In contrast, the ability of Xist to localize to the inactive X chromosome depends on the ability of Xist to bind to the sequence-specific transcription factor, YY1 Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Trans-acting antisense RNAs mediate transcriptional gene cosuppression in S. Controls telomerase access to telomeres in cell cycle phase-specific manner. Genome-wide views of chromatin structure. Further investigation into the molecular circuitry of ESCs showed that lincRNA genes are regulated by key transcription factors and that lincRNA transcripts physically bind to multiple chromatin regulatory proteins to affect shared gene expression programs. Binds to GR as a decoy and titrates GR away from target genes. Future studies will need to pinpoint potential lncRNA transcripts in these regions and discern whether and how the noncoding genome contributes to human diseases.
Non-coding transcription characterization and annotation: A guide and web resource for non-coding RNA databases. Article· Literature Review (PDF Available).
Alteration in RNA metabolism, concerning both coding and long non-coding RNAs The literature has put in light the role of lncRNAs in both. Evidence for selection within long noncoding RNAs. Genome . Multiplexed RNA structure characterization with selective.
RNA Biol. Genome-scale mapping of histone modifications and enhancer binding proteins have provided an additional layer of information to identify lncRNAs involved in gene activation.
Despite the observed pervasive transcription throughout the genome, pinpointing functional RNA molecules was tantamount to finding needles in a haystack.
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Journal of molecular biology. Chinnaiyan and colleague discovered a large set of lncRNAs in human prostate cancers by RNA-seq, and further identified PCAT-1, a lncRNA involved in gene repression that can identify poor prognosis patients based on its level in urine
of the protein-coding genes in tumors are in agreement with the literature data.
We present here NRDR, a Non-coding RNA Databases Resource for are characterized locally by computational analyses, (2) literature. Here we characterize lncRNAs by contrast to protein-coding RNAs .
Video: Noncoding rna characterization in literature Non-coding RNA (ncRNA) - Biomolecules - MCAT - Khan Academy
human micro and long noncoding RNAs based on literature-mining.
Antisense RNA stabilization induces transcriptional gene silencing via histone deacetylation in S. Identification of novel genes coding for small expressed RNAs. Although some portion lncRNAs may encode small peptides, we note this does not rule out the potential dual nature of lncRNAs acting through RNA and their protein products.
Repression of the human dihydrofolate reductase gene by a non-coding interfering transcript. Three main themes that encompass many of the examples discussed thus far Fig.
Genome regulation by long noncoding RNAs
Swissprot and PFAM.
Noncoding rna characterization in literature
|Similar to the classic idea of RNA serving as a signal for translation, lncRNAs could signal numerous other cellular processes.
RNA meets chromatin. Genome-wide views of chromatin structure. Guides: As described above Table 1many lncRNA are individually required for the proper localization of specific protein complexes. Nat Rev Genet. The phenomena recognized in the early 21 st century describing that a vast majority of the genome is transcriptionally active.